A series of case studies and pilot studies (and now one randomized controlled trial) have found high-dose thiamine useful for treating a range of neurological and immunological conditions. This website represents a work in progress to document the available research and describe potential mechanisms. Further research is needed to confirm the potential benefits and mechanisms of action.
A list of articles on high-dose thiamine may be found here.
Updated results from my survey of high-dose thiamine in people with ME/CFS, Fibromyalgia and Ehlers-Danlos Syndrome are available here here.